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Oncogene - Wikipedia
An oncogene is a gene that has the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels.. Most normal cells will undergo a programmed form of rapid cell death when critical functions are altered and malfunctioning.Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead.

RET proto-oncogene - Wikipedia
The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, [citation needed] while gain of function mutations are associated with the development of various types of human cancer ...

OMIM Entry - * 602533 - ONCOGENE DJ1; DJ1
Nagakubo et al. (1997) used yeast 2-hybrid screening of a HeLa cell library to clone a cDNA that encodes a novel 189-amino acid protein, termed DJ1. Northern blot analysis revealed that DJ1 is ubiquitously expressed as a 1.0-kb transcript. Western blot analysis and immunofluorescence showed that the DJ1 protein is present in both nuclei and cytoplasm of HeLa cells.

Oncogene - Wikipedia
Un oncogene è un gene, o una serie di nucleotidi che codificano una proteina, che potenzialmente indirizzano la cellula verso lo sviluppo di un fenotipo neoplastico.Solitamente gli oncogeni intervengono nello sviluppo tumorale e aumentano le possibilità che lo sviluppo (proliferazione e differenziamento) di una cellula si diriga in senso tumorale.

Thymine DNA glycosylase as a novel target for melanoma ...
Melanoma is an aggressive neoplasm with increasing incidence that is classified by the NCI as a recalcitrant cancer, i.e., a cancer with poor prognosis, lacking progress in diagnosis and treatment.

Intragenic origins due to short G1 phases underlie ...
Oncogene-induced DNA replication stress contributes critically to the genomic instability that is present in cancer 1,2,3,4.However, elucidating how oncogenes deregulate DNA replication has been ...

UpToDate
INTRODUCTION — A group of patients with non-small cell lung cancer (NSCLC) have tumors that contain an inversion in chromosome 2 that juxtaposes the 5' end of the echinoderm microtubule-associated protein-like 4 (EML4) gene with the 3' end of the anaplastic lymphoma kinase (ALK) gene, resulting in the novel fusion oncogene EML4-ALK [].This fusion oncogene rearrangement is transforming both ...

Glossary | Genes in Life
A abnormal result . A possible result of a screening test. An abnormal result does not determine a diagnosis, and means additional testing is needed to see if the individual has a condition. Also referred to as positive result. acquired mutations . A change within a sequence of DNA caused by environment factors (sun, radiation, or chemicals), aging, or chance.

 

 

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